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李梦琪 副教授

邮  箱:limengqi@xmu.edu.cn

职称/职务:副教授

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2009-2013年,伟德国际官网登录入口生物科学专业,学士学位;
2013-2019年,伟德国际官网登录入口生物化学与分子生物学专业,博士学位;
2019-2022年,伟德国际官网登录入口,博士后;
2023年,伟德BETVlCTOR1946,副教授
B.S. 2009-2013, Xiamen University, Biological Sciences;
Ph.D. 2013-2019, Xiamen University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Xiamen University, 2019-2022;
Associate Professor, School of Life Sciences, Xiamen University, 2023

主要致力于代谢生物学的研究,特别是不同细胞器以及其间的协同调控代谢的分子机制以及生理功能的研究。

代表性论文(# co-first author, * Corresponding author):

1. Zhang CS#, Zhang B#, Li M#, Wei X#, Gong K#, Li Z, Yao X, Wu J, Zhang C, Zhu M, Zhang L, Sun X, Zhan YH, Jiang Z, Zhao W, Zhong W, Zhuang X, Zhou D, Piao HL, Lin SC, Wang Z. Identification of serum metabolites enhancing inflammatory responses in COVID-19. Sci China Life Sci. 2022 Oct;65(10):1971-1984.
2. Zhang CS#, Li M#, Wang Y#, Li X#, Zong Y#, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC. The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab. 2022 Oct;4(10):1369-1401.
3. Li M#, Zhang CS, Feng JW, Wei X, Zhang C, Xie C, Wu Y, Hawley SA, Atrih A, Lamont DJ, Wang Z, Piao HL, Hardie DG, Lin SC. Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1. Cell Res. 2021 Apr;31(4):478-481.
4. Li M#, Zhang CS#, Zong Y#, Feng JW, et al., Lin SC*. Transient Receptor Potential V channels are essential for Glucose Sensing by Aldolase and AMPK. Cell Metabolism 30, 508–524, 2019.
5. Zong Y#, Zhang CS#, Li M#, Wang W#, Wang ZH, Simon A. H, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang CX, Ye ZY, Lin SY, Piao HL, D. G Hardie, Lin SC* Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research, 29:460–473, 2019
6. Zhang CS#, Hawley SA#, Zong Y#, Li M#, Wang ZC, Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG*, Lin SC*. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature
7. Zhang CS#, Li M#, Ma T#, Zong Y, Cui J, Feng JW, Wu, YQ, Lin SY, and Lin SC*. Metformin activates AMPK through the lysosomal pathway. Cell Metabolism 24, 521-2, 2016
8. Zhang CS#, Liu Q#, Li M#, Lin SY#, Peng YY, Wu D, Li TY, Fu Q, Jia WP, Wang XJ, Ma T, Zong Y, Cui JW, Pu CF, Lian GL, Guo GL, Ye ZY, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIF1alpha through facilitating hydroxylation and suppresses the Warburg effect. Cell Res. 25, 1025-42, 2015
9. Zhang CS#, Jiang B#,Li M#, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC*. The Lysosomal v-ATPase-Ragulator Complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism 20, 526-40, 2014

荣誉、奖励及参加学术团体的情况:

伟德国际官网登录入口南强青年拔尖人才(B类),2022年
中国生命科学十大进展,2017年
福建省优秀博士毕业论文,2019年
中国自然科学基金面上资助,2020年